Simplex, Inc

Complex problems require SIMPLEX solutions (TM)

Selected Papers Published by Simplex, Inc Consultants

Practice Area 1: Evaluation of Antihypertensive Treament using ABPM

-The Population RDH Index. A Novel Index and Graphical Method for Statistical Assessment of Antihypertensive Treatment Reduction, Duration, and Homogeneity
Aboy, M.; Fernandez, J.R.; Hermina, R.C.
Blood Pressure Monitoring. Volume: 11, Issue: 3, 2006
Page(s): 143-155

-The Individual RDH Index. A Novel Vector Index for Statistical Assessment of Antihypertensive Treatment Reduction, Duration, and Homogeneity
Aboy, M.; Fernandez, J.R.; Hermina, R.C.
Blood Pressure Monitoring. Volume: 11, Issue: 2, 2006
Page(s): 69-78

-Methodological Considerations in the Evaluation of the Duration of Action of Antihypertensive Therapy Using Ambulatory Blood Pressure Monitoring
Aboy, M.; Fernandez, J.R.; Hermina, R.C.
Blood Pressure Monitoring. Volume: 10, Issue: 3, 2005
Page(s): 111-115

Practice Area 2: Biomedical Signal Processing

- Pulse Morphology Visualization and Analysis of Intracranial Pressure
Ellis, T.; McNames, J.; Aboy, M.
IEEE Transactions on Biomedical Engineering, Volume: X, Issue: X, 2006
Page(s): In press

- Reliability and Accuracy of Heart Rate Variability Metrics versus ECG Segment Duration
McNames; Aboy, M
Medical & Biological Engineering and Computing, Volume: X, Issue: X, 2006
Page(s): In press (available online)

- An Automatic Algorithm for Stationary Segmentation of Extracellular Microelectrode Recordings
Aboy, M; Falkerberg, JH.
Medical & Biological Engineering and Computing, Volume: 44, Issue: 6, 2006
Page(s): 511-515

- Adaptive Modeling and Spectral Estimation of Nonstationary Biomedical Signals Based on Kalman Filtering
Aboy, M.; Márquez, O.W.; McNames, J.; Hornero, R.; Thong, T.; Goldstein, B.
IEEE Transactions on Biomedical Engineering, Volume: 52, Issue: 8, 2005
Page(s): 1485-1489

- Prediction of Paroxysmal Atrial Fibrillation by Analysis of Atrial Premature Complexes
Thong. T; Goldstein, B.; McNames. J; Aboy, M.
IEEE Transactions on Biomedical Engineering, Volume: 51, Issue: 4, 2004
Page(s): 561-569

- Pattern Matching Techniques Applied to Biomedical Signal Processing
Cuesta-Frau, D.; Mico Tormos, P.; Novak, D.; Aboy, M.
IIAS Transactions of Systems Research and Cybernetics Volume: 4, Issue: 1, 2004
Page(s): 29-35

Practice Area 3: Prediction of Fluid Responsivenss & Fluid Optimization

- A Novel Algorithm to Estimate the Pulse Pressure Variation Index
Aboy, M.; McNames. J; Thong, T.; Phillips, C.R..; Ellenby, M. Goldstein, B.
IEEE Transactions on Biomedical Engineering, Volume: 51, Issue: 12, 2004
Page(s): 2198 - 2203

Practice Area 4: Interpretation of Complex System Analysis Techniques in the Context of Biomedical Signal Analysis & Processing

- Interpretation of the Lempel-Ziv Complexity Measure in the Context of Biomedical Signal Analysis
Aboy, M.; Hornero, R; Abasalo, D.; Alvarez, D.
IEEE Transactions on Biomedical Engineering, Volume: 52, Issue: 10, 2006
Page(s): In press (available online)

- Interpretation of Approximate Entropy. Case Studies in the Analysis of Intracranial Pressure During Acute Elevations in Traumatic Brain Injury
Honero, R.; Aboy, M.; Abásalo, D.; McNames, J.; Goldstein, B.
IEEE Transactions on Biomedical Engineering, Volume: 52, Issue: 10 , 2005
Page(s): 1671-1680

- Complex Analysis of Intracranial Hypertension using Approximate Entropy
Honero, R.; Aboy M.; Abásalo, D.; Wakeland, W.; Goldstein, B.
Critical Care Medicine, Volume: 34, Issue: 1, 2006
Page(s): 87-95

- Variability, Regularity, and Complexity of Time Series Generated by Schizophrenic Patients and Control Subjects
Honero, R.; Abásalo, D.; Jimeno, N.; Sanchez, C.; Poza, J.; J.; Aboy, M.
IEEE Transactions on Biomedical Engineering, Volume: 52, Issue: 10, 2006
Page(s): 210-218

Practice Area 5: Medical Devices


- A Microcontroller-Based Portable Electrocardiograph Recorder
Segura-Juarez, J.J.; Cuesta-Frau, D.; Samblas-Pena, L.; Aboy, M.;
IEEE Transactions on Biomedical Engineering, Volume: 51 , Issue: 9 , 2004
Pages: 1686 - 1690



Selected Book Chapters & Peer-Revieew Proceedings Publications


- ICU Monitoring of Continuous Physiologic Signals - Engineering Aspects, Clinical Interpretation, and Future Directions
Goldstein, B.; McNames, J.; Ellenby, M.; Ibsen, L.; Jacques; S.; Aboy, M.; Thong, T.; Phillips, C
Crit. Care Med, Current Concepts in Pediatric Critical Care, Volume: 1, Issue: 1, 2004
Page(s): 201-229

- Clustering of Intracranial Pressure Using Hidden Markov Models
Novak, D.; Cuesta-Frau, D.; Aboy, M.; Goldstein, B.; Lhotska, L.
EMCSR-European Meetings on Cybernetics and Systems Research,
Volume: X, Issue: X, 2004
Page(s): accepted (in press)

- Morphology analysis of physiological signals using hidden Markov models
Novak, D.; Lhotska, L.; Al-ani, T.; Hamam, Y.; Cuesta-Frau, D.; Mico, P.; Aboy, M.;
Pattern Recognition, 2004. ICPR 2004. Proceedings of the 17th International Conference,
Volume: 3, 2004
Pages:754 - 757


- A Novel Statistical Model for Simulation of Pressure Signals
Aboy, M.; McNames, J.; Thong, T.
European Association for Speech, Signal and Image Processing (EURASIP), 2004.
Proceedings, 17th International EURASIP Conference BIOSIGNAL 2004, Volume:17
Page(s): 364-367

- Time-Delay Estimation between Arterial Blood Pressure and Intracranial Pressure Signals Based on Kalman Filtering
Aboy, M.; Marquez, O.W.; McNames, J.; Cuesta-Frau, D..
European Association for Speech, Signal and Image Processing (EURASIP), 2004.
Proceedings, 17th International EURASIP Conference BIOSIGNAL 2004, Volume: 17
Page(s): 355-357

- Complex Analysis of Intracranial Hypertension in Traumatic Brain Injury using Approximate Entropy
Hornero, R.; Abasolo, D.E.; Aboy, M.; Mcnames, J.; Goldstein, B.
European Association for Speech, Signal and Image Processing (EURASIP), 2004.
Proceedings, 17th International EURASIP Conference BIOSIGNAL 2004, Volume: 17
Page(s): 15-17

- Averaged Lomb Periodograms for Nonuniform Sampling
Thong, T.; McNames, J.; Aboy, M.; Oken, B.
European Association for Speech, Signal and Image Processing (EURASIP), 2004.
Proceedings, 17th International EURASIP Conference BIOSIGNAL 2004, Volume: 17
Page(s): 39-41

- A Database of Occulographic Signals
Cuesta-Frau, D.; Novak, D.; Aboy, M.; Brzezny, R.; Cerny, R.; Jerabek, J.
European Association for Speech, Signal and Image Processing (EURASIP), 2004.
Proceedings, 17th International EURASIP Conference BIOSIGNAL 2004, Volume: 17
Page(s): 97-99

- Designing Portable Biomedical Signal Recorders
Cuesta-Frau, D.; Segura-Juarez, J.J; Aboy, M.; Samblas-Pena, L.
European Association for Speech, Signal and Image Processing (EURASIP), 2004.
Proceedings, 17th International EURASIP Conference BIOSIGNAL 2004, Volume: 17
Page(s): 155-157

- Transient Pulse Morphology Analysis of Intracranial Pressure after Ventricular Drainage
Aboy, M.; Crespo, C.; McNames. J; Ellenby, M; Goldstein, B.
Society of Critical Care Medicine.
Critical Care Medicine (Part 2 Suppl.), Volume: 31, Number: 12, 2003
Page(s): 334


- Evidence for Diminished Complexity During Acute Hypotension in Sepsis
Aboy, M.; McNames. J.; Goldstein, B.
Society of Critical Care Medicine.
Critical Care Medicine (Part 2 Suppl.), Volume: 31, Number: 12, 2003
Page(s): 229

- Response Analysis of Intracranial Pressure to Changes in Respiratory Rate
Levitte, G.; Aboy, M.; McNames. J.; Goldstein, B.
Society of Critical Care Medicine.
Critical Care Medicine (Part 2 Suppl.), Volume: 31, Number: 12, 2003
Page(s): 333

- Significance of Intracranial Pressure Pulse Morphology in Pediatric Traumatic Brain Injury
Aboy, M.; McNames, J.; Cuesta-Frau, D.; Wakeland, W.; Thong, T.; Lai, S.; Gold
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 3, 2003
Page(s): 2491-2494

- Pulse Pressure Variation Estimation Based on Rank-Order Fitlers
Aboy, M.; McNames, J.; Thong, T; Phillips, C.R.; Ellenby, M.S.; Goldstein, B.
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 3, 2003
Page(s): 2435-2438

- Paroxysmal Atrial Fibrillation Prediction Using Isolated Premature Atrial Events and Paroxysmal Atrial Tachycardia
Thong. T. ; McNames. J; Aboy, M. Goldstein, B
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 1, 2003
Page(s): 163-166

- Morphology Analysis of Intracranial Pressure Using Pattern Matching Techniques
Cuesta-Frau, D.; Aboy, M.; McNames, J.; Goldstein, B.
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 3, 2003
Page(s): 2917-2920

- Biosignal Laboratory: A Software Tool for Complete Biomedical Signal Processing
Cuesta-Frau, D.; Mico, P; Aboy, M.; Novak, D; Brezny, R.; Samblas, L; Pastor, D; Sancho, D.
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 4, 2003
Page(s): 3544-3547

- Adaptive Comb Filter for Semi-Periodic Signals
Cyrill, D.; McNames, J.; Aboy, M.
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 3, 2003
Page(s): 2439-2442

- A New Resource for Independent and Blinded Assessment of QRS Detection Algorithms
Tsunami, D.; McNames, J.; Aboy, M. Ellenby, M.
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 3, 2003
Page(s): 2889-2892



- Segmentation of Extracellular Microelectrode Recordings with Equal Power
Falkenberg, J.H.; McNames, J.; Aboy, M.; Burchiel, K.J.
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: 3, 2003
Page(s): 2475-2478

- Stationarity of Ultra-Short Heart Rate Variability Measures
Thong. T. ; Kehai, L; McNames. J; Aboy, M. Goldstein, B
IEEE Engineering in Medicine and Biology Society (EMBS), 2003.
Proceedings of the 25th International Conference of the IEEE, Volume: X, 2003
Page(s): 2424-2427

- Transient Pulse Morphology Analysis of the Intracranial Pressure Signal After Ventricular Drainage
Aboy, M.; McNames. J.; Wakeland, W.; Ellenby, M.; Desiree, H.; Lai, S.; Goldstein, B.
International Symposium Intracranial Pressure and Brain Monitoring, 2003.
Proceedings of the 12th International Symposium Intracranial Pressure and Brain Monitoring Volume: X, Number: X, 2003
Page(s): 402-405

- Intracranial Pressure Pulse Amplitude and Mean Intracranial Pressure Analysis in Pediatric Traumatic Brain Injury
Aboy, M.; McNames. J.; Wakeland, W.; Ellenby, M.; Desiree, H.; Lai, S.; Goldstein, B.
International Symposium Intracranial Pressure and Brain Monitoring, 2003.
Proceedings of the 12th International Symposium Intracranial Pressure and Brain Monitoring Volume: X, Number: X, 2003
Page(s): accepted

- Evidence for Diminished Complexity During Intracranial Hypertension in Traumatic Brain Injury
Aboy, M.; Crespo, C.; McNames. J; Ellenby, M; Goldstein, B.
Society of Critical Care Medicine, December 2002.
Critical Care Medicine, Volume: 30, Number: 12, 2002
Page(s): A80 (355)

- Automatic Detection Algorithm for Physiologic Pressure Signal Components
Aboy, M.; Crespo, C.; McNames. J; Goldstein, B.
IEEE Engineering in Medicine and Biology Society (EMBS), 2002.
Proceedings of the 24th International Conference of the IEEE, Volume: 1, 2002
Page(s): 196-197

- Harmonic Spectrogram for the Analysis of Semi-Periodic Signals
McNames, J.; Crespo, C.; Aboy, M.; Bassale, J.; Jenkins, L.; Goldstein, B.
IEEE Engineering in Medicine and Biology Society (EMBS), 2002.
Proceedings of the 24th International Conference of the IEEE, Volume: 1, 2002
Page(s): 143-44

- A Biomedical Signal Processing Toolbox
Aboy, M.; Crespo, C.; McNames, J.; Bassale, J.; Jenkins, L.; Goldstein, B.
European Association for Speech, Signal and Image Processing (EURASIP), 2002.
Proceedings of the 16th International EURASIP Conference BIOSIGNAL 2002, Volume: 16, 2002
Page(s): 49-52 vol. 16

- Techniques for the Visualization of Nonstationary Biomedical Signals
McNames, J.; Bassale, J.; Aboy, M.; Crespo, C.; Goldstein, B.
European Association for Speech, Signal and Image Processing (EURASIP), 2002.
Proceedings of the 16th International EURASIP Conference BIOSIGNAL 2002, Volume: 16, 2002
Page(s): 42-45 vol. 16

- Precursors in the Arterial Blood Pressure Signal to Episodes of Acute Hypotension in Sepsis
C
respo, C.; McNames, J.; Aboy, M.; Bassale, J.; Ellenby, M.; Lai, S.; Goldstein, B.
European Association for Speech, Signal and Image Processing (EURASIP), 2002.
Proceedings of the 16th International EURASIP Conference BIOSIGNAL 2002, Volume: 16, 2002
Page(s): 206-208 vol. 16

- Sensitive Precursors to Acute Episodes of Intracranial Hypertension
McNames, J.; Crespo, C.; Bassale, J.; Aboy, M.; Ellenby, M.; Lai, S.; Goldstein, B.
Proceedings of the 4th International Workshop Biosignal Interpretation, 2002
Page(s): 303-306


- Changes in the Blood Pressure Signal Autocorrelation Function Prior To Hypotension in Septic Shock
Bassale, J.; McNames, J.; Ellenby, M.; Aboy, M.; Crespo, C.; Lai, S.; Goldstein, B.
Critical Care Medicine, 2001. Volume: 29, No. 12/SS
Page(s): A112-A113

- Automatic Detection Algorithm of Intracranial Pressure Waveform Components
Aboy, M.; McNames, J.; Goldstein, B.
IEEE Engineering in Medicine and Biology Society (EMBS), 2001.
Proceedings of the 23th International Conference of the IEEE, Volume: 3, 2001
Page(s): 2231-2234

- Precursors to Rapid Elevations in Intracranial Pressure
McNames, J.; Crespo, C.; Aboy, M.; Ellenby, M.; Lai, S.; Sclabassi, R.; Goldstein, B.
IEEE Engineering in Medicine and Biology Society (EMBS), 2001.
Proceedings of the 23th International Conference of the IEEE, Volume: 4, 2001
Page(s): 3977-3980
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Selected Peer-Reviewed Publications
-IEEE Transactions on Biomedical Engineering: 11
-Medical & Biological Engineering & Computing: 3
-Blood Pressure Monitoring: 3
-Critical Care Medicine: 2
-Medical Engienering & Physics: 1
We have extensive experience in R&D, design, innovation, and strategy development in the fields of biomedical signal processing, medical devices, digital signal processing, bioinformatics, and algorithm development.
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